Learn how to use this product
Simple, rapid, and efficient electrophoretic tissue clearing
Spend your time more efficiently and decrease your time spent on preparing, sectioning, labeling, mounting, imaging and analyzing those hundreds of ultra-thin slices when you want to analyze tissues. The X-CLARITY II offers you the ultimate solution for electrophoretic tissue clearing: prepare your tissue in its whole for further histology and imaging analysis.
Tissue clearing with X-CLARITY II: how it works
With the X-CLARITY II you clear whole tissues from their lipid bilayers (through electrophoresis in the presence of ionic detergents) while keeping the biomolecules intact, which are covalently linked to a sturdy hydrogel network.
This tissue clearing method preserves the molecular information and structural integrity of a tissue sample and leaves you with a stable and transparant tissue-hydrogel hybrid. This hybrid can be efficiently penetrated by and labeled with antibodies or oligonucleotides for further phenotyping.
Experience the upgraded X-CLARITY Tissue Clearing II with enhanced features:
Innovative & simple touchscreen interface
New & improved module for precise temperature control
Active and passive clearing modes
Exportable data monitoring clearing conditions
Clearing chamber with plated electrodes for steady electric field
Due to the active and passive tissue clearing modes and the availability of holders of various sizes, a wide range of tissue types can be cleared with the X-CLARITY II. See more tissues that can be cleared with the X-Clarity here.
Tissue clearing workflow
The superfast and efficient workflow of X-CLARITY II tissue clearing involves four steps:
Incubation of the tissue sample in a hydrogel monomer solution to allow uniform hydrogel diffusion throughout the whole sample
Polymerization to form the stable hydrogel-tissue hybrid
Clearing of the lipid bilayers in the tissue-hydrogel hybrid through electrophoresis in the presence of ionic detergents
Labeling and imaging of your whole tissue
What X-CLARITY Tissue Clearing users say
