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phosphoTAU ELISA (CE)
Learn how to use this product The phosphoTAU ELISA is an enzyme immunoassay intended for the quantitative determination of phosphorylated tau in human cerebrospinal fluid (CSF) for supporting diagnosis of Alzheimer’s disease (AD). The development of Alzheimer’s disease is characterized by three stages, as defined by the US National Institute on Aging workgroups:
1. a preclinical stage of Alzheimer’s Disease,
2. the mild cognitive impairment (MCI) stage due to AD and
3. dementia stage due to AD.
Phosphorylated tau in CSF shows at least comparable diagnostic specificity and sensitivity to other diagnostic available tests for Alzheimer’s disease.
Specifications: 3.5h protocol; 25 µl CSF required Cut-Off: 51 pg/ml (each laboratory must establish its own Cut-Off values) Analytical Sensitivity (Limit of detection): 15 pg/ml (Mean signal negative control (blank) + 3xSD) Clinical Sensitivity: 87 % (AD/MCI patients: n=64; Controls: n=37) Clinical Specifity: 92 % (AD/MCI patients: n=64; Controls: n=37) Area under ROC-curve (AUC): 97.1 %