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Desthiobiotin is a modified form of biotin that displaces Strep-tag®II and Twin-Strep-tag® fusion proteins from the modified biotin-binding pocket of Strep-Tactin® in a competitive manner, resulting in a mild elution. Desthiobiotin powder can be used to prepare Strep-Tactin® elution buffer, Buffer E. It should be noted that desthiobiotin is not applicable for elution from Strep-Tactin®XT resins.